Macrophage colony-stimulating factor mediates astrocyte-induced microglial ramification in human fetal central nervous system culture.

@article{Liu1994MacrophageCF,
  title={Macrophage colony-stimulating factor mediates astrocyte-induced microglial ramification in human fetal central nervous system culture.},
  author={Wei Liu and Celia F. Brosnan and Dennis W. Dickson and S. P. C. Lee},
  journal={The American journal of pathology},
  year={1994},
  volume={145 1},
  pages={48-53}
}
Colony-stimulating factors are important mediators of microglial growth and function. Microglia, derived from ameboid precursor cells, undergo a series of morphological changes in the central nervous system to become ramified, a morphological hallmark of differentiated microglia. The cellular mechanisms and environmental factors involved in microglial ramification in the developing brain are not known. In the present study, we examined the role of macrophage colony-stimulating factor (M-CSF) in… CONTINUE READING
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