Macrophage colony-stimulating factor is expressed by an ovarian carcinoma subline and stimulates the c-myc proto-oncogene.

@article{Krupitza1995MacrophageCF,
  title={Macrophage colony-stimulating factor is expressed by an ovarian carcinoma subline and stimulates the c-myc proto-oncogene.},
  author={Georg Krupitza and Rodolphe Fritsch{\'e} and E. Dittrich and Hanna Harant and Heinz Huber and Thomas W. Grunt and Ch Dittrich},
  journal={British Journal of Cancer},
  year={1995},
  volume={72},
  pages={35 - 40}
}
A small, fast-growing and non-differentiated clone (N.1) derived from the heterogeneous human epithelial ovarian carcinoma cell line HOC-7 produces an autocrine/paracrine factor that is secreted into the cell culture supernatant. This factor is capable of enhancing mRNA levels of the proliferation-related oncogene c-myc in the more differentiated clone D3 and in normal human fibroblasts MRC.5, but also in N.1 cells themselves. Supernatants enriched for this paracrine/autocrine factor also… CONTINUE READING
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