Macrophage colony-stimulating factor induces substantial osteoclast generation and bone resorption in human bone marrow cultures.

@article{Sarma1996MacrophageCF,
  title={Macrophage colony-stimulating factor induces substantial osteoclast generation and bone resorption in human bone marrow cultures.},
  author={U. M. B. S. Sarma and Adrienne Margaret Flanagan},
  journal={Blood},
  year={1996},
  volume={88 7},
  pages={2531-40}
}
Macrophage colony-stimulating factor (M-CSF) is essential for murine osteoclast formation and its role in human hematopoiesis in vitro is not fully defined. Therefore, we have investigated the effect of M-CSF on the formation of human osteoclasts in vitro. M-CSF was found to induce substantial bone resorption and osteoclast formation in a dose-responsive and time-dependent manner above that induced by 1,25 dihydroxyvitamin D3 (1,25 vitamin D3) in cultures of human bone marrow (BM) stromal cells… CONTINUE READING

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