Macrophage colony-stimulating factor in human fetal astrocytes and microglia. Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia.

@article{Lee1993MacrophageCF,
  title={Macrophage colony-stimulating factor in human fetal astrocytes and microglia. Differential regulation by cytokines and lipopolysaccharide, and modulation of class II MHC on microglia.},
  author={S. P. C. Lee and Wei Liu and Patrick Roth and Dennis W. Dickson and Joan W Berman and Celia F. Brosnan},
  journal={Journal of immunology},
  year={1993},
  volume={150 2},
  pages={594-604}
}
CSF-1 is a growth factor that selectively promotes the proliferation, survival, and differentiation of cells of the mononuclear phagocyte series. As part of a study on the role of cytokine and hematopoietic growth factors in central nervous system (CNS) development and inflammation, we examined the expression of CSF-1 in dissociated glial cells cultured from human fetal CNS tissue. CSF-1 mRNA and protein were constitutively expressed by astrocytes. The steady state level of CSF-1 mRNA was… CONTINUE READING

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