Macrophage colony-stimulating factor enhances the susceptibility of macrophages to infection by human immunodeficiency virus and reduces the activity of compounds that inhibit virus binding.

@article{Bergamini1994MacrophageCF,
  title={Macrophage colony-stimulating factor enhances the susceptibility of macrophages to infection by human immunodeficiency virus and reduces the activity of compounds that inhibit virus binding.},
  author={Alberto Bergamini and Carlo Federico Perno and Luciana Dini and Marcella Capozzi and Caterina Pesce and Luca Ventura and L Cappannoli and Laura Falasca and Giulio Milanese and Raffaele Cali{\`o}},
  journal={Blood},
  year={1994},
  volume={84 10},
  pages={
          3405-12
        }
}
The effects of macrophage colony-stimulating factor (M-CSF) on CD4 receptor expression, susceptibility to human immunodeficiency virus type 1 (HIV) infection, and anti-HIV activity of dextran sulfate and soluble-CD4 were studied in cultured, human primary macrophages. M-CSF stimulated macrophage cells to express the CD4 receptor, and this resulted in an increase of both the number of CD4+ cells and the density of the receptor on the cell surface. M-CSF also significantly enhanced the… CONTINUE READING

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