Macrophage colony-stimulating factor enhancement of antibody-dependent cellular cytotoxicity against human colon carcinoma cells.

@article{Qi1995MacrophageCF,
  title={Macrophage colony-stimulating factor enhancement of antibody-dependent cellular cytotoxicity against human colon carcinoma cells.},
  author={C. F. Qi and Carol A. Nieroda and Rosaria De Filippi and John W. Greiner and Pierpaolo Correale and Jeffrey Schlom and Kwong Yok Tsang},
  journal={Immunology letters},
  year={1995},
  volume={47 1-2},
  pages={15-24}
}
Antibody-dependent cellular cytotoxicity (ADCC) has been suggested to be an important defense mechanism against tumors. The effects of recombinant human macrophage colony-stimulating factor (rhM-CSF) on ADCC activity of human monocytes were investigated. Human peripheral monocytes were pre-incubated for 72 h with rhM-CSF at various concentrations (50, 100, 200, 400 U/ml) and then used as effector cells in a 24-h 111-Indium release assay. Human carcinoma cell lines LS-174T, CBS, and KLE were… CONTINUE READING