Macrophage and monocyte IL-1 beta regulation differs at multiple sites. Messenger RNA expression, translation, and post-translational processing.

@article{Herzyk1992MacrophageAM,
  title={Macrophage and monocyte IL-1 beta regulation differs at multiple sites. Messenger RNA expression, translation, and post-translational processing.},
  author={Danuta J. Herzyk and James N Allen and Clay B. Marsh and Mark D Wewers},
  journal={Journal of immunology},
  year={1992},
  volume={149 9},
  pages={3052-8}
}
Maturation of blood monocytes into macrophages is accompanied by a number of functional changes including decreased IL-1 beta release in response to LPS. This limitation has previously been ascribed to transcriptional regulation. However, in seeming conflict with the observed depression in IL-1 beta mRNA levels, recent work demonstrates increased intracellular IL-1 beta in macrophages. Therefore, the present study sought to explain these differences by comparing IL-1 beta production from… CONTINUE READING

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