Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation

@inproceedings{Magnusson2016MacrophageAD,
  title={Macrophage and dendritic cell subsets in IBD: ALDH+ cells are reduced in colon tissue of patients with ulcerative colitis regardless of inflammation},
  author={Maria K Magnusson and Siggeir F Brynjolfsson and Anders Dige and Heli Uronen-Hansson and Lars G. B{\"o}rjesson and Jonas L. Bengtsson and Sigurdur V Gudjonsson and Lena {\"O}hman and J\orgen S Agnholt and Henrik Sj{\"o}vall and William W. Agace and Mary Jo Wick},
  booktitle={Mucosal immunology},
  year={2016}
}
Disruption of the homeostatic balance of intestinal dendritic cells (DCs) and macrophages (MQs) may contribute to inflammatory bowel disease. We characterized DC and MQ populations, including their ability to produce retinoic acid, in clinical material encompassing Crohn's ileitis, Crohn's colitis and ulcerative colitis (UC) as well as mesenteric lymph nodes (MLNs) draining these sites. Increased CD14(+)DR(int) MQs characterized inflamed intestinal mucosa while total CD141(+) or CD1c(+) DCs… CONTINUE READING