Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF.

@article{Craxton2003MacrophageAD,
  title={Macrophage- and dendritic cell--dependent regulation of human B-cell proliferation requires the TNF family ligand BAFF.},
  author={Andrew Craxton and Dario M. Magaletti and Elizabeth J Ryan and Edward A. Clark},
  journal={Blood},
  year={2003},
  volume={101 11},
  pages={
          4464-71
        }
}
Macrophages and dendritic cells play an important role in regulating B-cell responses, including proliferation to antigens such as trinitrophenyl (TNP)-Ficoll and TNP-Brucella abortus. However, the mechanisms and molecule(s) that regulate these processes are relatively undefined. In this report, we show that human macrophages generated in vitro strongly costimulate proliferation of dense human tonsillar B cells ligated via their B-cell antigen receptor (BCR) but not proliferation via CD40… CONTINUE READING

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