Macrophage activation through CCR5‐ and CXCR4‐mediated gp120‐elicited signaling pathways

@article{Lee2003MacrophageAT,
  title={Macrophage activation through CCR5‐ and CXCR4‐mediated gp120‐elicited signaling pathways},
  author={ChuHee Lee and Qing‐Hua Liu and Brian E. Tomkowicz and Yanjie Yi and Bruce D Freedman and Ronald G. Collman},
  journal={Journal of Leukocyte Biology},
  year={2003},
  volume={74}
}
Macrophages are major targets for infection by human immunodeficiency virus type 1 (HIV‐1). In addition to their role as productive viral reservoirs, inappropriate activation of infected and uninfected macrophages appears to contribute to pathogenesis. HIV‐1 infection requires initial interactions between the viral envelope surface glycoprotein gp120, the cell‐surface protein CD4, and a chemokine receptor CCR5 or CXCR4. Besides their role in HIV‐1 entry, CCR5 and CXCR4 are G protein‐coupled… 
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