Macrophage activation syndrome: a frequent but under-diagnosed complication associated with rheumatic diseases.

@article{Tristano2008MacrophageAS,
  title={Macrophage activation syndrome: a frequent but under-diagnosed complication associated with rheumatic diseases.},
  author={Antonio G. Tristano},
  journal={Medical science monitor : international medical journal of experimental and clinical research},
  year={2008},
  volume={14 3},
  pages={RA27-36}
}
Macrophage activation syndrome (MAS) or hemophagocytic syndrome is a severe complication of chronic rheumatic diseases especially in systemic-onset juvenile rheumatoid arthritis (JRA). Although the cause of MAS is unknown, dysregulation of macrophage-lymphocyte interactions with subsequent increases in the levels of both T cell-derived and macrophage-derived cytokines could be involved in this syndrome, leading to an intense systemic inflammatory reaction, which accounts for the main clinical… CONTINUE READING
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