Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma

@inproceedings{Hong2014MacrophageAS,
  title={Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma},
  author={Jun Young Hong and Yutein Chung and Jessica M Steenrod and Qiang Chen and Jing Lei and Adam T. Comstock and Adam M Goldsmith and J Kelley Bentley and Umadevi S Sajjan and Marc B Hershenson},
  booktitle={Respiratory research},
  year={2014}
}
BACKGROUND The mechanisms by which viruses cause asthma exacerbations are not precisely known. Previously, we showed that, in ovalbumin (OVA)-sensitized and -challenged mice with allergic airway inflammation, rhinovirus (RV) infection increases type 2 cytokine production from alternatively-activated (M2) airway macrophages, enhancing eosinophilic inflammation and airways hyperresponsiveness. In this paper, we tested the hypothesis that IL-4 signaling determines the state of macrophage… CONTINUE READING
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