Macrophage activation marker, soluble CD163, is an independent predictor of short‐term mortality in patients with cirrhosis and bacterial infection

@article{Tornai2016MacrophageAM,
  title={Macrophage activation marker, soluble CD163, is an independent predictor of short‐term mortality in patients with cirrhosis and bacterial infection},
  author={Tam{\'a}s Tornai and Zsuzsanna Vit{\'a}lis and N{\'o}ra Sipeki and Tam{\'a}s Dinya and David Tornai and P{\'e}ter Antal-Szalm{\'a}s and Zsolt Kar{\'a}nyi and Istvan Tornai and M{\'a}ria Papp},
  journal={Liver International},
  year={2016},
  volume={36},
  pages={1628 - 1638}
}
Innate immune system dysfunction is common in advanced cirrhosis, with a central role of the monocyte/macrophage system. Monocytes and macrophages express the scavenger receptor CD163, which is regulated by inflammatory mediators. Cleavage of the receptor leads to the formation of soluble (s)CD163 that represents an anti‐inflammatory response. We aimed to study the clinical importance of sCD163 in cirrhosis. 
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