Macrophage activation marker, soluble CD163, is an independent predictor of short‐term mortality in patients with cirrhosis and bacterial infection

  title={Macrophage activation marker, soluble CD163, is an independent predictor of short‐term mortality in patients with cirrhosis and bacterial infection},
  author={Tam{\'a}s Tornai and Zsuzsanna Vit{\'a}lis and N{\'o}ra Sipeki and Tam{\'a}s Dinya and David Tornai and P{\'e}ter Antal-Szalm{\'a}s and Zsolt Kar{\'a}nyi and Istvan Tornai and M{\'a}ria Papp},
  journal={Liver International},
  pages={1628 - 1638}
Innate immune system dysfunction is common in advanced cirrhosis, with a central role of the monocyte/macrophage system. Monocytes and macrophages express the scavenger receptor CD163, which is regulated by inflammatory mediators. Cleavage of the receptor leads to the formation of soluble (s)CD163 that represents an anti‐inflammatory response. We aimed to study the clinical importance of sCD163 in cirrhosis. 
Lectin‐complement pathway molecules are decreased in patients with cirrhosis and constitute the risk of bacterial infections
  • I. Foldi, T. Tornai, M. Papp
  • Biology, Medicine
    Liver international : official journal of the International Association for the Study of the Liver
  • 2017
The significance of low level of these molecules in the development of cirrhosis‐associated bacterial infections, which has not been elucidated so far, is studied.
Functional polymorphisms of innate immunity receptors are not risk factors for the non‐SBP type bacterial infections in cirrhosis
  • T. Dinya, T. Tornai, M. Papp
  • Biology, Medicine
    Liver international : official journal of the International Association for the Study of the Liver
  • 2018
Their role in the development of cirrhosis‐associated bacterial infections (BI), beyond SBP or progressive disease course related to pathological bacterial translocation (BT) remains unknown.
Causes and Consequences of Innate Immune Dysfunction in Cirrhosis
Knowledge of the phenotypic manifestation and pathophysiological mechanisms of cirrhosis associated immunosuppression may lead to immune targeted therapies to reduce susceptibility to infection in patients with Cirrhosis, and better biomarkers for risk stratification, and assessment of efficacy of novel immunotherapies.
Editorial: macrophage activation markers predict prognosis and decompensation in patients with cirrhosis—linking gut permeability, inflammation and cirrhosis progression
A nationwide non-medical switch from originator infliximab to biosimilar CT-P13 in 802 patients with inflammatory arthritis: 1-year clinical outcomes from the DANBIO registry.
Elevated neopterin levels are associated with acute-on-chronic liver failure and mortality in patients with liver cirrhosis.
  • Camila Matiollo, E. C. M. Rateke, LL Schiavon
  • Medicine, Biology
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2020
Presepsin: A potential biomarker of PJI? A comparative analysis with known and new infection biomarkers
Presepsin can be considered a useful tool for the diagnosis and clinical monitoring of PJI and can be backed by a panel of new inflammatory markers involved in monocyte-/macrophage-mediated inflammatory responses, such as OPN, CCL2, TLR2, and suPAR.
Abnormal Innate Immunity in Acute-on-Chronic Liver Failure: Immunotargets for Therapeutics
The defects of different innate immune cells in ACLF are discussed which updates the current knowledge of innate immune response and provide potential targets for new therapeutic interventions.
Major Changes of von Willebrand Factor Multimer Distribution in Cirrhotic Patients with Stable Disease or Acute Decompensation
In AD patients, highly increased VWF and reduced ADAMTS13 activity could be found, along with the presence of ULMWM, which are possible markers and contributors of the disease progression.


Soluble CD163, a marker of Kupffer cell activation, is related to portal hypertension in patients with liver cirrhosis
Activation of Kupffer cells may be involved in the pathogenesis of portal hypertension by release of vasoconstrictive substances and fibrosis due to co‐activation of hepatic stellate cells.
Soluble urokinase plasminogen activator receptor is compartmentally regulated in decompensated cirrhosis and indicates immune activation and short‐term mortality
The regulation and prognostic relevance of elevated concentrations of soluble urokinase plasminogen activator receptor (suPAR) in patients with advanced cirrhosis were studied to identify patients who require intensified treatment.
Secretory leukocyte protease inhibitor: A pivotal mediator of anti‐inflammatory responses in acetaminophen‐induced acute liver failure
SLPI is a pivotal mediator of anti‐inflammatory responses in AALF through modulation of monocyte/macrophage function, which may account for the susceptibility to sepsis in A ALF.
Admission levels and early changes in serum interleukin‐10 are predictive of poor outcome in acute liver failure and decompensated cirrhosis
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  • Medicine
    Liver international : official journal of the International Association for the Study of the Liver
  • 2010
The prognostic value of admission IL‐10 levels and their evolution during the early phase of treatment in intensive care, in comparison to the pro‐inflammatory cytokines IL‐6 and tumour necrosis factor (TNF)‐α, is investigated.
Tumor necrosis factor α‐converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163
The present results provide a likely explanation for the strong empirical relationship between the sCD163 plasma level and infectious/inflammatory diseases relating to macrophage activity.
Hepatic Macrophage Activation and the LPS Pathway in Patients With Alcoholic Hepatitis: A Prospective Cohort Study
The hepatic inflammation of human AH involves marked activation of hepatic macrophages, likely via the LPS pathway, and may present a target for biological therapy of AH.
Soluble CD163
  • H. Møller
  • Biology, Medicine
    Scandinavian journal of clinical and laboratory investigation
  • 2012
It is now evident that sCD163 is very useful as a biomarker of macrophages activation in various inflammatory diseases, such as macrophage activation syndrome, sepsis, and liver disease, and is a general risk marker of comorbidity and mortality in several chronic inflammatory disease states.