Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process

@inproceedings{TorreMinguela2016MacrophageAA,
  title={Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process},
  author={Carlos de Torre-Minguela and Mar{\'i}a Barber{\`a}-Cremades and Ana I. G{\'o}mez and F{\'a}tima Mart{\'i}n-S{\'a}nchez and Pablo Pelegr{\'i}n},
  booktitle={Scientific reports},
  year={2016}
}
The activation of P2X7 receptor (P2X7R) on M1 polarized macrophages induces the assembly of the NLRP3 inflammasome leading to the release of pro-inflammatory cytokines and the establishment of the inflammatory response. However, P2X7R signaling to the NLRP3 inflammasome is uncoupled on M2 macrophages without changes on receptor activation. In this study, we analyzed P2X7R secretome in wild-type and P2X7R-deficient macrophages polarized either to M1 or M2 and proved that proteins released after… CONTINUE READING