Macrophage-Tropic HIV Induces and Exploits Dendritic Cell Chemotaxis

  title={Macrophage-Tropic HIV Induces and Exploits Dendritic Cell Chemotaxis},
  author={C L Lin and Andrew K. Sewell and George F. Gao and Kathryn T. Whelan and Rodney E. Phillips and Jonathan M. Austyn},
  journal={The Journal of Experimental Medicine},
  pages={587 - 594}
Immature dendritic cells (iDCs) express the CC chemokine receptor (CCR)5, which promotes chemotaxis toward the CC chemokines regulated on activation, normal T cell expressed and secreted (RANTES), macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta. By contrast, mature DCs downregulate CCR5 but upregulate CXC chemokine receptor (CXCR)4, and as a result exhibit enhanced chemotaxis toward stromal cell-derived factor (SDF)-1alpha. CCR5 and CXCR4 also function as coreceptors for macrophage… CONTINUE READING