Macrophage Replication Screen Identifies a Novel Francisella Hydroperoxide Resistance Protein Involved in Virulence

@inproceedings{Llewellyn2011MacrophageRS,
  title={Macrophage Replication Screen Identifies a Novel Francisella Hydroperoxide Resistance Protein Involved in Virulence},
  author={Anna C. Llewellyn and Crystal L. Jones and Brooke A Napier and James E Bina and David S Weiss},
  booktitle={PloS one},
  year={2011}
}
Francisella tularensis is a gram-negative facultative intracellular pathogen and the causative agent of tularemia. Recently, genome-wide screens have identified Francisella genes required for virulence in mice. However, the mechanisms by which most of the corresponding proteins contribute to pathogenesis are still largely unknown. To further elucidate the roles of these virulence determinants in Francisella pathogenesis, we tested whether each gene was required for replication of the model… CONTINUE READING
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Mechanisms of Francisella tularensis intracellular pathogenesis.

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