Macrophage Polarization.

@article{Murray2017MacrophageP,
  title={Macrophage Polarization.},
  author={Peter J. Murray},
  journal={Annual review of physiology},
  year={2017},
  volume={79},
  pages={
          541-566
        }
}
  • P. Murray
  • Published 2017
  • Medicine
  • Annual review of physiology
Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and the normal tissue environment. Three broad pathways control polarization: epigenetic and cell survival pathways that prolong or shorten macrophage development and viability, the tissue microenvironment, and extrinsic factors, such as microbial… Expand
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References

SHOWING 1-10 OF 131 REFERENCES
Obstacles and opportunities for understanding macrophage polarization
TLDR
Current features of macrophage polarization are summarized and the roles of variousmacrophage subpopulations and macrophages‐associated genes in health and disease are discussed. Expand
Control of macrophage metabolism and activation by mTOR and Akt signaling.
TLDR
How mTOR and Akt, major metabolic regulators and targets of such activation signals, control macrophage metabolism and activation are discussed to pave the way to the development of new therapeutic strategies. Expand
The M1 and M2 paradigm of macrophage activation: time for reassessment
TLDR
How cytokines and pathogen signals influence macrophages' functional phenotypes and the evidence for M1 and M2 functions is assessed and a paradigm initially based on the role of a restricted set of selected ligands in the immune response is revisited. Expand
Regulation of macrophage development and function in peripheral tissues
TLDR
It is suggested that most macrophages seed the tissues during embryonic development and functionally specialize in response to cytokines and metabolites that are released by the stroma and drive the expression of unique transcription factors. Expand
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis.
TLDR
A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny. Expand
Molecular control of activation and priming in macrophages
TLDR
Recent findings that advance the understanding of mechanisms underlying priming and signal-dependent activation of macrophages are reviewed and the effect of genetic variation on these processes is discussed. Expand
Control of macrophage activation and function by PPARs.
  • A. Chawla
  • Biology, Medicine
  • Circulation research
  • 2010
TLDR
The mechanisms by which peroxisome proliferator-activated receptors (PPARs) transcriptionally regulate macrophage activation in health and disease states, including obesity, insulin resistance and cardiovascular disease, are reviewed. Expand
The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis
TLDR
It is argued that epigenetic regulation of macrophages is determined by lineage- and tissue-specific transcription factors controlled by the built-in programming of myeloid development in combination with signaling from the tissue environment. Expand
Regulation of Macrophage Polarization by the STAT–SOCS Signaling Axis
TLDR
The Suppressors Of Cytokine Signaling (SOCS) proteins have emerged as important negative regulators of JAK/STAT signaling, functioning largely as part of a negative feedback loop. Expand
Tissue-Resident Macrophage Ontogeny and Homeostasis.
TLDR
The exact nature of the embryonic progenitors that give rise to adult tissue-resident macrophages is still debated, and the mechanisms enabling macrophage population maintenance in the adult are undefined. Expand
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