Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages

  title={Macrophage Polarisation: an Immunohistochemical Approach for Identifying M1 and M2 Macrophages},
  author={M{\'a}rio Henrique Magalh{\~a}es Barros and Franziska Hauck and Johannes H. Dreyer and Bettina Kempkes and Gerald U. Niedobitek},
  booktitle={PloS one},
Macrophage polarization is increasingly recognised as an important pathogenetic factor in inflammatory and neoplastic diseases. Proinflammatory M1 macrophages promote T helper (Th) 1 responses and show tumoricidal activity. M2 macrophages contribute to tissue repair and promote Th2 responses. CD68 and CD163 are used to identify macrophages in tissue sections. However, characterisation of polarised macrophages in situ has remained difficult. Macrophage polarisation is regulated by transcription… CONTINUE READING


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