Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer’s Disease

@inproceedings{Kassaar2017MacrophageMI,
  title={Macrophage Migration Inhibitory Factor is subjected to glucose modification and oxidation in Alzheimer’s Disease},
  author={Omar Kassaar and Marta P. Pereira Morais and Suying Xu and Emily L. Adam and Rosemary C. Chamberlain and Bryony Jenkins and Tony D James and Paul T Francis and Stephen Geoffrey Ward and Robert J Williams and Jean M.H. van den Elsen},
  booktitle={Scientific reports},
  year={2017}
}
Glucose and glucose metabolites are able to adversely modify proteins through a non-enzymatic reaction called glycation, which is associated with the pathology of Alzheimer's Disease (AD) and is a characteristic of the hyperglycaemia induced by diabetes. However, the precise protein glycation profile that characterises AD is poorly defined and the molecular link between hyperglycaemia and AD is unknown. In this study, we define an early glycation profile of human brain using fluorescent… CONTINUE READING
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