Macrophage Migration Inhibitory Factor Is Induced by Thrombin and Factor Xa in Endothelial Cells*

@article{Shimizu2004MacrophageMI,
  title={Macrophage Migration Inhibitory Factor Is Induced by Thrombin and Factor Xa in Endothelial Cells*},
  author={Tadamichi Shimizu and Jun Nishihira and Hirokazu Watanabe and Riichiro Abe and Ayumi Honda and Teruo Ishibashi and Hiroshi Shimizu},
  journal={Journal of Biological Chemistry},
  year={2004},
  volume={279},
  pages={13729 - 13737}
}
Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has been shown to play a role in wound-healing processes. In this study, we investigated whether protease-activated receptor (PAR)-1 and PAR-2 mediated MIF expression in human endothelial cells. Thrombin, factor Xa (FXa), and trypsin induced MIF expression in human dermal microvascular endothelial cells and human umbilical vein endothelial cells, but other proteases, including kallikrein and urokinase, failed to do so… Expand
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  • Medicine
  • Frontiers in bioscience : a journal and virtual library
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