Macrophage Migration Inhibitory Factor Activates Hypoxia-Inducible Factor in a p53-Dependent Manner

@article{Oda2008MacrophageMI,
  title={Macrophage Migration Inhibitory Factor Activates Hypoxia-Inducible Factor in a p53-Dependent Manner},
  author={Seiko Oda and Tomoyuki Oda and Kenichiro Nishi and Satoshi Takabuchi and Takuhiko Wakamatsu and Tomoharu Tanaka and Takehiko Adachi and Kazuhiko Fukuda and Gregg L Semenza and Kiichi Hirota},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={791 - 800}
}
BACKGROUND Macrophage migration inhibitory factor (MIF) is not only a cytokine which has a critical role in several inflammatory conditions but also has endocrine and enzymatic functions. MIF is identified as an intracellular signaling molecule and is implicated in the process of tumor progression, and also strongly enhances neovascularization. Overexpression of MIF has been observed in tumors from various organs. MIF is one of the genes induced by hypoxia in an hypoxia-inducible factor 1 (HIF… CONTINUE READING
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