Macrophage Inflammatory Protein 3α Is Involved in the Constitutive Trafficking of Epidermal Langerhans Cells

@article{Charbonnier1999MacrophageIP,
  title={Macrophage Inflammatory Protein 3α Is Involved in the Constitutive Trafficking of Epidermal Langerhans Cells},
  author={A S Charbonnier and Norbert Kohrgruber and Ernst Kriehuber and Georg Stingl and Antal Rot and Dieter Maurer},
  journal={The Journal of Experimental Medicine},
  year={1999},
  volume={190},
  pages={1755 - 1768}
}
Certain types of dendritic cells (DCs) appear in inflammatory lesions of various etiologies, whereas other DCs, e.g., Langerhans cells (LCs), populate peripheral organs constitutively. Until now, the molecular mechanism behind such differential behavior has not been elucidated. Here, we show that CD1a(+) LC precursors respond selectively and specifically to the CC chemokine macrophage inflammatory protein (MIP)-3alpha. In contrast, CD14(+) precursors of DC and monocytes are not attracted by MIP… CONTINUE READING

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