Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer.

@article{Quaranta2018MacrophageDerivedGD,
  title={Macrophage-Derived Granulin Drives Resistance to Immune Checkpoint Inhibition in Metastatic Pancreatic Cancer.},
  author={Valeria Quaranta and Carolyn Rainer and Sebastian R Nielsen and Meirion L Raymant and Muhammad S Ahmed and Dannielle D Engle and Arthur R. Taylor and Trish Murray and Fiona Campbell and Daniel H. Palmer and David A Tuveson and Ainhoa Mielgo and Michael C Schmid},
  journal={Cancer research},
  year={2018},
  volume={78 15},
  pages={
          4253-4269
        }
}
The ability of disseminated cancer cells to evade the immune response is a critical step for efficient metastatic progression. Protection against an immune attack is often provided by the tumor microenvironment that suppresses and excludes cytotoxic CD8+ T cells. Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive metastatic disease with unmet needs, yet the immunoprotective role of the metastatic tumor microenvironment in pancreatic cancer is not completely understood. In this study… CONTINUE READING
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