Macrophage CD31 Signaling in Dissecting Aortic Aneurysm.

  title={Macrophage CD31 Signaling in Dissecting Aortic Aneurysm.},
  author={Francesco Andreata and Varouna Syvannarath and Marc Cl{\'e}ment and Sandrine Delbosc and Kevin Guedj and Giulia Fornasa and Jamila Khallou-Laschet and Marion Morvan and Guillaume Even and Emanuele Procopio and A Gaston and Marie Le Borgne and Lydia Deschamps and A Nicoletti and Giuseppina Caligiuri},
  journal={Journal of the American College of Cardiology},
  volume={72 1},
BACKGROUND The authors recently found that a CD31 agonist peptide reaches macrophages in injured aortas and exerts beneficial effects on apolipoprotein E-knockout (Apo E-/-) mice subjected to angiotensin (Ang) II infusion, a model of experimental acute aortic dissection and intramural hematoma (ADIM). OBJECTIVES The purpose of this study was to evaluate the therapeutic potential of a drug-suitable agonist peptide in experimental ADIM. METHODS P8RI, a retro-inverso sequence of the best… CONTINUE READING
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