Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer.

@article{Moughon2015MacrophageBU,
  title={Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer.},
  author={Diana Louise Moughon and Huanhuan He and Shiruyeh Schokrpur and Ziyue Karen Jiang and Madeeha Yaqoob and John David and Crystal Chi-Sheng Lin and M Luisa Iruela-Arispe and Oliver Dorigo and Lily H. Wu},
  journal={Cancer research},
  year={2015},
  volume={75 22},
  pages={
          4742-52
        }
}
Malignant ascites is a common complication in the late stages of epithelial ovarian cancer (EOC) that greatly diminishes the quality of life of patients. Malignant ascites is a known consequence of vascular dysfunction, but current approved treatments are not effective in preventing fluid accumulation. In this study, we investigated an alternative strategy of targeting macrophage functions to reverse the vascular pathology of malignant ascites using fluid from human patients and an… CONTINUE READING
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A phase II study of aflibercept in patients with advanced epithelial Targeting CSF1R to Block TAMs Eases EOC Malignant Ascites www.aacrjournals.org Cancer Res

  • N Colombo, G Mangili, S Mammoliti, M Kalling, B Tholander, L Sternas
  • November 15,
  • 2015
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