Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote

  title={Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote},
  author={J. Eisen and R. Coyne and M. Wu and D. Wu and M. Thiagarajan and J. Wortman and J. Badger and Q. Ren and P. Amedeo and K. M. Jones and L. Tallon and A. Delcher and S. Salzberg and J. Silva and B. Haas and William H. Majoros and M. Farzad and J. Carlton and R. Smith and J. Garg and R. Pearlman and K. Karrer and L. Sun and G. Manning and N. Elde and A. Turkewitz and D. Asai and D. E. Wilkes and Y. Wang and H. Cai and K. Collins and B. A. Stewart and S. Lee and K. Wilamowska and Z. Weinberg and W. Ruzzo and D. Wloga and J. Gaertig and J. Frankel and Che-Chia Tsao and M. Gorovsky and P. Keeling and R. Waller and N. Patron and J. Cherry and Nicholas A. Stover and C. Krieger and Christina del Toro and Hilary F Ryder and Sondra C Williamson and Rebecca A Barbeau and E. Hamilton and E. Orias},
  journal={PLoS Biology},
  • J. Eisen, R. Coyne, +50 authors E. Orias
  • Published 2006
  • Biology, Medicine
  • PLoS Biology
  • The ciliate Tetrahymena thermophila is a model organism for molecular and cellular biology. Like other ciliates, this species has separate germline and soma functions that are embodied by distinct nuclei within a single cell. The germline-like micronucleus (MIC) has its genome held in reserve for sexual reproduction. The soma-like macronucleus (MAC), which possesses a genome processed from that of the MIC, is the center of gene expression and does not directly contribute DNA to sexual progeny… CONTINUE READING
    637 Citations
    Macronuclear genome structure of the ciliate Nyctotherus ovalis: Single-gene chromosomes and tiny introns
    • 35
    Structure of the germline genome of Tetrahymena thermophila and relationship to the massively rearranged somatic genome
    • 78
    Gene expression in a paleopolyploid: a transcriptome resource for the ciliate Paramecium tetraurelia
    • 59
    • PDF
    Genome plasticity in Paramecium bursaria revealed by population genomics
    • Highly Influenced
    • PDF
    Analysis of sequence variability in the macronuclear DNA of Paramecium tetraurelia: a somatic view of the germline.
    • 68
    • PDF
    Extraordinary genome stability in the ciliate Paramecium tetraurelia
    • 92
    • PDF


    Cell biology of Tetrahymena thermophila.
    • J. Frankel
    • Biology, Medicine
    • Methods in cell biology
    • 2000
    • 138
    The genome of the social amoeba Dictyostelium discoideum
    • 1,193
    • PDF
    Tetrahymena genetics: two nuclei are better than one.
    • K. Karrer
    • Biology, Medicine
    • Methods in cell biology
    • 2000
    • 110
    The genome sequence of the filamentous fungus Neurospora crassa
    • 1,555
    • PDF
    High Coding Density on the Largest Paramecium tetraurelia Somatic Chromosome
    • 48
    Toward Sequencing the Tetrahymena Genome: Exploiting the Gift of Nuclear Dimorphism
    • E. Orias
    • Biology, Medicine
    • The Journal of eukaryotic microbiology
    • 2000
    • 22
    A novel family of mobile genetic elements is limited to the germline genome in Tetrahymena thermophila.
    • 80
    • PDF
    RNA-guided DNA deletion in Tetrahymena: an RNAi-based mechanism for programmed genome rearrangements.
    • 118
    Patterns of protein evolution in Tetrahymena thermophila: implications for estimates of effective population size.
    • 37
    • PDF
    The Highly Conserved Family of Tetrahymena thermophila Chromosome Breakage Elements Contains an Invariant 10-Base-Pair Core
    • 22
    • PDF