Macromolecular transport in synapse to nucleus communication.

  title={Macromolecular transport in synapse to nucleus communication.},
  author={Nicolas Panayotis and A. B. Karpova and Michael R Kreutz and Mike Fainzilber},
  journal={Trends in neurosciences},
  volume={38 2},
Local signaling events at synapses or axon terminals must be communicated to the nucleus to elicit transcriptional responses. The lengths of neuronal processes pose a significant challenge for such intracellular communication. This challenge is met by mechanisms ranging from rapid signals encoded in calcium waves to slower macromolecular signaling complexes carried by molecular motors. Here we summarize recent findings on macromolecular signaling from the synapse to the nucleus, in comparison… CONTINUE READING
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