Macromolecular crowding effect is critical for maintaining SIRT1's nuclear localization in cancer cells.

@article{Sun2016MacromolecularCE,
  title={Macromolecular crowding effect is critical for maintaining SIRT1's nuclear localization in cancer cells.},
  author={Lidong Sun and Jia Fang},
  journal={Cell cycle},
  year={2016},
  volume={15 19},
  pages={
          2647-2655
        }
}
SIRT1 is a principle class III histone deacetylase which exhibits versatile functions in stress response, development, and pathological processes including cancer. Although SIRT1 deacetylates a wide range of nuclear and cytoplasmic proteins, its subcellular localization in cancer cells has been controversial. In this study, we uncovered the inconsistent reports about SIRT1 subcellular localization is partially due to different analysis approaches. While immunofluorescence and live cell imaging… CONTINUE READING