Macromerine, normacromerine and bisnormacromerine: Non-psychoactive methylated derivatives of norepinephrine

  title={Macromerine, normacromerine and bisnormacromerine: Non-psychoactive methylated derivatives of norepinephrine},
  author={Wolfgang H. Vogel and B. D. Evans and Eric M. Bonnem and J F Fischer and Jerry McLaughlin},
Macromerine, normacromerine and bisnormacromerine, O and/or N methylated derivatives of norepinephrine, produce no effect on the conditioned avoidance response (CAR) in rats after IP injection of up to 100 mg/kg of the corresponding hydrochloride. The fate of these compounds was studied by a newly developed assay method utilizing an extraction procedure and the native fluorescence of the compounds. The compounds are rapidly absorbed from the peritoneal cavity, show a half-life of 30 to 60 min… 
1 Citations
Stimulus properties of mescaline and N-methylated derivatives: Difference in peripheral and direct central administration
It is concluded that NMM and DMM, two possible metabolites of mescalin, apparently do not play a significant role in the mescaline-induced internal stimuli.


Structure-activity relationship studies on mescaline
The results indicate that only two analogues of mescaline are active and that the 3,4,5 configuration is necessary and that adding extra methoxy groups increases activity.
Relation between the action of dopamine and apomorphine and their O-methylated derivatives upon the CNS
SummaryThe syndrome of gnaw-compulsion was studied in rats providing evidence for a structure-effect relationship between the alcaloid apomorphine and the normal metabolite in the brain, dopamine.The
Physiological disposition and metabolism of 3,4-dimethoxyphenylethylamine in the rat.
  • W. Vogel
  • Biology, Medicine
    International journal of neuropharmacology
  • 1968
Distribution, metabolism and excretion of bufotenine in the rat with preliminary studies of its O-methyl derivative.
  • E. Sanders, M. T. Bush
  • Chemistry, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1967
Studies of the biologic fate of bufoatenine and O-methyl-bufo-tenine in the rat are presented. The syntheses of these compounds labeled with C 14 and methods for estimation of unchanged compounds and
Two new alkaloids in cacti.
An assay procedure for mescaline and its determination in rat brain, liver and plasma
Eine Schnellmethode zur Bestimmung von Meskalin in Geweben and biologischen Flüssigkeiten wird beschrieben und ein Vergleich zwischen MesKalin und zwei verwandten Verbindungen wurde angestellt.
Behavioural Models of Psychosis
Studies on the biological basis of psychosis are currently being conducted in a variety of disciplines and using a wide range of techniques (Smythies, 1968). These include studies of the basic
Structure–Activity Relationships of One-Ring Psychotomimetics
Human dose-response relationships for psychotomimetic phenethylamines : an isopropylamine side chain and triple methoxy substitution provide optimum activity. Available data suggest possible
Schizophrenia: a new approach.
The close biochemical relationship between adrenaline and mescaline appears to be significant in conjunction with the clinical relationship between acute mescalin intoxication and acute schizophrenia and between the latter condition and stress.