Macrolides and airway inflammation in children.

  title={Macrolides and airway inflammation in children.},
  author={Masaharu Shinkai and Bruce K. Rubin},
  journal={Paediatric respiratory reviews},
  volume={6 3},
For more than 20 years macrolide antibiotics have been used to treat chronic inflammatory airway diseases based on their immunomodulatory activity. Macrolide antibiotics down-regulate damaging prolonged inflammation as well as increase mucus clearance, decrease bacterial virulence and prevent biofilm formation. Initially shown to decrease morbidity and mortality in diffuse panbronchiolitis and in steroid-dependent asthma, long-term macrolide therapy has now been shown to significantly reduce… CONTINUE READING


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