Macrolide resistance in Helicobacter pylori: rapid detection of point mutations and assays of macrolide binding to ribosomes.

@article{Occhialini1997MacrolideRI,
  title={Macrolide resistance in Helicobacter pylori: rapid detection of point mutations and assays of macrolide binding to ribosomes.},
  author={Alessandra Occhialini and M Urdaci and Florence Doucet-Populaire and C{\'e}cile Marie B{\'e}bear and H{\'e}rve Lamouliatte and Francis M{\'e}graud},
  journal={Antimicrobial agents and chemotherapy},
  year={1997},
  volume={41 12},
  pages={2724-8}
}
Resistance of Helicobacter pylori to macrolides is a major cause of failure of eradication therapies. Single base substitutions in the H. pylori 23S rRNA genes have been associated with macrolide resistance in the United States. Our goal was to extend this work to European strains, to determine the consequence of this mutation on erythromycin binding to H. pylori ribosomes, and to find a quick method to detect the mutation. Seven pairs of H. pylori strains were used, the parent strain being… CONTINUE READING

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