Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells

Abstract

The specific 26S proteasome inhibitor bortezomib (BZ) potently induces autophagy, endoplasmic reticulum (ER) stress and apoptosis in multiple myeloma (MM) cell lines (U266, IM-9 and RPMI8226). The macrolide antibiotics including concanamycin A, erythromycin (EM), clarithromycin (CAM) and azithromycin (AZM) all blocked autophagy flux, as assessed by… (More)
DOI: 10.3892/ijo.2013.1870

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@inproceedings{Moriya2013MacrolideAB, title={Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells}, author={Shota Moriya and Xiao-Fang Che and Seiichiro Komatsu and Akihisa Abe and Tomohiro Kawaguchi and Akihiko Gotoh and Masato Inazu and Akio Tomoda and Keisuke Miyazawa}, booktitle={International journal of oncology}, year={2013} }