Macrolide antibiotics allosterically predispose the ribosome for translation arrest.

@article{Sothiselvam2014MacrolideAA,
  title={Macrolide antibiotics allosterically predispose the ribosome for translation arrest.},
  author={Shanmugapriya Sothiselvam and Bao Liu and Wei Han and Haripriya Ramu and Dorota Klepacki and Gemma C. Atkinson and Age Brauer and Maido Remm and Tanel Tenson and Klaus Schulten and Nora V{\'a}zquez-Laslop and Alexander S Mankin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 27},
  pages={9804-9}
}
Translation arrest directed by nascent peptides and small cofactors controls expression of important bacterial and eukaryotic genes, including antibiotic resistance genes, activated by binding of macrolide drugs to the ribosome. Previous studies suggested that specific interactions between the nascent peptide and the antibiotic in the ribosomal exit tunnel… CONTINUE READING