Macroglobulin-Producing Plasma-Cell Tumor in Mice: Identification of a New Light Chain.

@article{McIntimif1965MacroglobulinProducingPT,
  title={Macroglobulin-Producing Plasma-Cell Tumor in Mice: Identification of a New Light Chain.},
  author={K R McIntimif and Richard Asofsky and Michael L Potter and E. L. Kuff},
  journal={Science},
  year={1965},
  volume={150 3694},
  pages={361-3}
}
A transplantable plasmacell tumor in mice produces both a gammaM-macroglobulin serum protein with a sedimentation coefficient of 17S and a kappa-type urinary protein. The reduced and alkylated macroglobulin, when examined by electrophoresis in acid-urea polyacrylamide gel, had a fast component which migrated in the same position as the urinary protein and also a slow component. These two components, as shown by exclusion chromatography, represent the light and heavy polypeptide chains of the… CONTINUE READING