Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis.

@article{Guo2011MacroglialPA,
  title={Macroglial plasticity and the origins of reactive astroglia in experimental autoimmune encephalomyelitis.},
  author={Fuzheng Guo and Yoshiko Maeda and Joyce Ma and M C Gamero Delgado and Jiho Sohn and Laird Miers and Emily Mills Ko and Peter G Bannerman and Jie Xu and Yazhou Wang and Chengji J. Zhou and Hirohide Takebayashi and David Pleasure},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 33},
  pages={11914-28}
}
Accumulations of hypertrophic, intensely glial fibrillary acidic protein-positive (GFAP(+)) astroglia, which also express immunoreactive nestin and vimentin, are prominent features of multiple sclerosis lesions. The issues of the cellular origin of hypertrophic GFAP(+)/vimentin(+)/nestin(+) "reactive" astroglia and also the plasticities and lineage relationships among three macroglial progenitor populations-oligodendrocyte progenitor cells (OPCs), astrocytes and ependymal cells-during multiple… CONTINUE READING