Macroflux® Microprojection Array Patch Technology: A New and Efficient Approach for Intracutaneous Immunization

@article{Matriano2002MacrofluxMA,
  title={Macroflux® Microprojection Array Patch Technology: A New and Efficient Approach for Intracutaneous Immunization},
  author={James A. Matriano and Michel Cormier and Juanita Johnson and Wendy A. Young and Margaret Buttery and Kofi Nyam and Peter E. Daddona},
  journal={Pharmaceutical Research},
  year={2002},
  volume={19},
  pages={63-70}
}
Purpose. We evaluated the Macroflux® microprojection array patch technology as a novel system for intracutaneous delivery of protein antigens. Methods. Macroflux® microprojection array systems (330-μm microprojection length, 190 microprojections/cm2, 1- and 2-cm2 area) were coated with a model protein antigen, ovalbumin (OVA), to produce a dry-film coating. After system application, microprojection penetration depth, OVA delivery, and comparative immune responses were evaluated in a hairless… CONTINUE READING