Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial

@article{Taylor2005MacrofilaricidalAA,
  title={Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial},
  author={Mark J Taylor and W. Makunde and Helen F. McGarry and J. Turner and S. Mand and A. Hoerauf},
  journal={The Lancet},
  year={2005},
  volume={365},
  pages={2116-2121}
}
BACKGROUND Wolbachia endosymbionts of filarial nematodes are vital for larval development and adult-worm fertility and viability. This essential dependency on the bacterium for survival of the parasites has provided a new approach to treat filariasis with antibiotics. We used this strategy to investigate the effects of doxycycline treatment on the major cause of lymphatic filariasis, Wuchereria bancrofti. METHODS We undertook a double-blind, randomised, placebo-controlled field trial of… Expand
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Therapeutic trial of doxycyclin plus ivermectin for the treatment of Brugia malayi naturally infected cats.
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