Macrocytosis, macrocytic anemia, and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men.

@article{Yokoyama2014MacrocytosisMA,
  title={Macrocytosis, macrocytic anemia, and genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 in Japanese alcoholic men.},
  author={Akira Yokoyama and Tetsuji Yokoyama and Philip J. Brooks and Takeshi Mizukami and Toshifumi Matsui and Mitsuru Kimura and Sachio Matsushita and Susumu Higuchi and Katsuya Maruyama},
  journal={Alcoholism, clinical and experimental research},
  year={2014},
  volume={38 5},
  pages={1237-46}
}
BACKGROUND Oxidation of ethanol by alcohol dehydrogenase (ADH) generates acetaldehyde (AcH), which is converted to acetate by aldehyde dehydrogenase-2 (ALDH2). Roughly 40% of East Asians are ALDH2-deficient due to an inactive enzyme encoded by the ALDH2*2 allele. ALDH2-deficient individuals have a dramatically elevated risk of esophageal cancer from alcohol consumption. METHODS We investigated the relationship between ALDH2*2, ADH1B*2 (encoding a highly active ADH) and erythrocyte… CONTINUE READING
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