Macrocyclic G-quadruplex ligands.

  title={Macrocyclic G-quadruplex ligands.},
  author={Mads Corvinius Nielsen and Trond Ulven},
  journal={Current medicinal chemistry},
  volume={17 29},
G-quadruplex stabilizing compounds have recently received increased interest due to their potential application as anticancer therapeutics. A significant number of structurally diverse G-quadruplex ligands have been developed. Some of the most potent and selective ligands currently known are macrocyclic structures which have been modeled after the natural product telomestatin or from porphyrin-based ligands discovered in the late 1990s. These two structural classes of G-quadruplex ligands are… CONTINUE READING