Macrocycles as potential therapeutic agents in neglected diseases.

@article{Pea2015MacrocyclesAP,
  title={Macrocycles as potential therapeutic agents in neglected diseases.},
  author={Stella Pe{\~n}a and Laura Scarone and Gloria Serra},
  journal={Future medicinal chemistry},
  year={2015},
  volume={7 3},
  pages={355-82}
}
Macrocycles possess desirable properties that make them promising candidates for the discovery of novel drugs. They present structural features to favor bioactive conformations, selectivity to the receptors, cell permeability and metabolic stability. More effective and nontoxic drugs to cure human African trypanosomiasis, Leishmaniasis and Chagas disease are needed, especially because resistance has been detected. Therefore, major efforts should be made for investigation in new bioactive… CONTINUE READING