Macrocycles as drug-enhancing excipients in pharmaceutical formulations

@article{Gu2021MacrocyclesAD,
  title={Macrocycles as drug-enhancing excipients in pharmaceutical formulations},
  author={Alice Gu and Nial J. Wheate},
  journal={Journal of Inclusion Phenomena and Macrocyclic Chemistry},
  year={2021},
  volume={100},
  pages={55 - 69}
}
  • Alice Gu, N. Wheate
  • Published 6 April 2021
  • Biology, Chemistry
  • Journal of Inclusion Phenomena and Macrocyclic Chemistry
The macrocycle families: cucurbit[n]urils, n-cyclodextrins, calix[n]arenes, and pillar[n]arenes (where n represents the number of subunits in each homologue) have shown considerable potential as drug-enhancing excipients for a range of pharmaceutical applications. Each macrocycle can form host–guest complexes with active pharmaceutical ingredients (API) where binding is stabilised by hydrophobic effects within each macrocycles’ cavity and through hydrogen bonds/ion–dipole bonds/electrostatic… 
Encapsulation of Metronidazole in Biocompatible Macrocycles and Structural Characterization of Its Nano Spray-Dried Nanostructured Composite
TLDR
The produced protonated metronidazole–SCX4 complex induced nanoparticle formation with protonate chitosan by supramolecular crosslinking of the polysaccharide chains and the properties of the aqueous nanoparticle solutions and the micron-sized solid composite produced therefrom by nano spray drying were unraveled.
Supramolecular Coronation of Platinum(II) Complexes by Macrocycles: Structure, Relativistic DFT Calculations, and Biological Effects.
TLDR
The development of a supramolecular host-guest system built on cationic platinum(II) compounds bearing ligands anchored in the cavity of the macrocyclic host achieves the same cellular uptake as cisplatin and cisPlatin@β-CD, respectively, while maintaining a significantly lower toxicity profile.
Insulin Complexation with Cyclodextrins—A Molecular Modeling Approach
Around 5% of the population of the world is affected with the disease called diabetes mellitus. The main medication of the diabetes is the insulin; the active form is the insulin monomer, which is an
A study to assess the viability of novel in-situ techniques for determining chloroform in drinking water in developing countries
The aim of this study was to research appropriate methods for the in-situ analysis of chloroform and other disinfection by-products (DBPs) in drinking water and then assess the viability of these

References

SHOWING 1-10 OF 142 REFERENCES
Host-Guest Complexes of Carboxylated Pillar[n]arenes With Drugs.
Effects of cyclodextrins on the chemical stability of drugs.
Comparative macrocycle binding of the anticancer drug phenanthriplatin by cucurbit[n]urils, β-cyclodextrin and para-sulfonatocalix[4]arene: a 1H NMR and molecular modelling study
TLDR
The results show that para-sulfonatocalix[4]arene is the only suitable macrocycle of the four studied for further research into phenanthriplatin drug delivery and indicate that cucurbit[7]uril binds over the long arm of the drug, where hydrophobic effects and two hydrogen bonds stabilise binding.
Toxicology and Drug Delivery by Cucurbit[n]uril Type Molecular Containers
TLDR
Very low toxicity of five members of the cucurbit[n]uril family of nanocontainers is revealed, demonstrating the uptake of containers by cells and intracellular release of container-loaded drugs.
The potential of cucurbit[n]urils in drug delivery
TLDR
The potential use of cucurbiturils in drug delivery in the context of getting a new drug into clinical trials is examined and what further research is needed in this area is discussed.
Cyclodextrin-Based Formulations: A Non-Invasive Platform for Targeted Drug Delivery.
TLDR
An overview of chemical properties, mechanisms of CDs on drug solubilization, stabilization and permeation, along with their toxicological profiles relevant to nasal and ocular administration, are provided and discussed.
The use of cyclodextrin inclusion complexes to improve anticancer drug profiles: a systematic review
TLDR
It was showed that cyclodextrin/anticancer drug complexes enhance solubility, reduce toxicity, and improve therapeutic efficacy in in vivo tumor models in the pharmacokinetic studies detailed and described below.
Cucurbit[7]uril encapsulated cisplatin overcomes cisplatin resistance via a pharmacokinetic effect.
TLDR
The results provide the first example of overcoming drug resistance via a purely pharmacokinetic effect rather than drug design or better tumour targeting, and demonstrate that in vitro assays are no longer as important in screening advanced systems of drug delivery.
Host–guest complexes of the antituberculosis drugs pyrazinamide and isoniazid with cucurbit[7]uril
The potential use of cucurbit[7]uril (CB[7]) as an excipient in oral formulations for improved drug physical stability or for improved drug delivery was examined with the antituberculosis drugs
...
1
2
3
4
5
...