Macrocycles as drug-enhancing excipients in pharmaceutical formulations

  title={Macrocycles as drug-enhancing excipients in pharmaceutical formulations},
  author={Alice Gu and Nial J. Wheate},
  journal={Journal of Inclusion Phenomena and Macrocyclic Chemistry},
  pages={55 - 69}
  • Alice Gu, N. Wheate
  • Published 6 April 2021
  • Biology, Chemistry
  • Journal of Inclusion Phenomena and Macrocyclic Chemistry
The macrocycle families: cucurbit[n]urils, n-cyclodextrins, calix[n]arenes, and pillar[n]arenes (where n represents the number of subunits in each homologue) have shown considerable potential as drug-enhancing excipients for a range of pharmaceutical applications. Each macrocycle can form host–guest complexes with active pharmaceutical ingredients (API) where binding is stabilised by hydrophobic effects within each macrocycles’ cavity and through hydrogen bonds/ion–dipole bonds/electrostatic… 
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