Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

@article{Blackwell1980MacrocortinAP,
  title={Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids},
  author={G. J. Blackwell and Rosa Carnuccio and Massimo Di Rosa and Roderick John Flower and Luca Parente and Paola Persico},
  journal={Nature},
  year={1980},
  volume={287},
  pages={147-149}
}
Anti-inflammatory glucocorticoids inhibit prostaglandin (PG) biosynthesis by preventing arachidonic acid release from phos-pholipids rather than inhibiting the cyclooxygenase1–16. As in other cells17–19, this steroid action depends on receptor occupation and de novo protein/RNA biosynthesis12–16. We have previously shown in guinea pig perfused lungs and rat peritoneal leukocytes that the effect of steroids on PG generation is mediated by an uncharacterized ‘second messenger’13,16. Now, we… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 136 CITATIONS, ESTIMATED 50% COVERAGE

CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features.

  • Molecular cancer research : MCR
  • 2014
VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Dysmenorrhea and Menorrhagia

  • Springer International Publishing
  • 2018
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1982
2019

CITATION STATISTICS

  • 3 Highly Influenced Citations