Macroamylasemia and other immunoglobulin-complexed enzyme disorders.

  title={Macroamylasemia and other immunoglobulin-complexed enzyme disorders.},
  author={David C. Klonoff},
  journal={The Western journal of medicine},
  volume={133 5},
Macroamylase is a circulating complex of immunoglobulin linked to normal amylase in most cases. Its physical properties are heterogeneous, but its large size impairs renal filtration. Macroamylasemia usually causes hyperamylasemia and an amylase clearance:creatinine clearance (C(AM):C(CR)) ratio of less than 1 percent. Macroamylasemia occurs in 2.5 percent… CONTINUE READING