MacroEvoLution: A New Method for the Rapid Generation of Novel Scaffold‐Diverse Macrocyclic Libraries

@inproceedings{Saupe2017MacroEvoLutionAN,
  title={MacroEvoLution: A New Method for the Rapid Generation of Novel Scaffold‐Diverse Macrocyclic Libraries},
  author={J{\"o}rn Saupe and Oliver Kunz and Lars Ole Haustedt and Sven Jakupovic and Christian Mang},
  booktitle={Chemistry},
  year={2017}
}
Macrocycles are a structural class bearing great promise for future challenges in medicinal chemistry. Nevertheless, there are few flexible approaches for the rapid generation of structurally diverse macrocyclic compound collections. Here, an efficient method for the generation of novel macrocyclic peptide-based scaffolds is reported. The process, named here as "MacroEvoLution", is based on a cyclization screening approach that gives reliable access to novel macrocyclic architectures… CONTINUE READING

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