Macro- to microscale strain transfer in fibrous tissues is heterogeneous and tissue-specific.

@article{Han2013MacroTM,
  title={Macro- to microscale strain transfer in fibrous tissues is heterogeneous and tissue-specific.},
  author={Woojin M. Han and S. J. Heo and Tristan P. Driscoll and Lachlan J. Smith and Robert L Mauck and Dawn M. Elliott},
  journal={Biophysical journal},
  year={2013},
  volume={105 3},
  pages={807-17}
}
Mechanical deformation applied at the joint or tissue level is transmitted through the macroscale extracellular matrix to the microscale local matrix, where it is transduced to cells within these tissues and modulates tissue growth, maintenance, and repair. The objective of this study was to investigate how applied tissue strain is transferred through the local matrix to the cell and nucleus in meniscus, tendon, and the annulus fibrosus, as well as in stem cell-seeded scaffolds engineered to… CONTINUE READING

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