Macitentan for the Treatment of Pulmonary Arterial Hypertension

  title={Macitentan for the Treatment of Pulmonary Arterial Hypertension},
  author={Irene Seunghyun Hong and Holly V Coe and Linda M. Catanzaro},
  journal={Annals of Pharmacotherapy},
  pages={538 - 547}
Objective: To review the pharmacology, safety, and efficacy of macitentan. Data Sources: PubMed, EMBASE, and were searched using the terms macitentan and ACT-064992. Study Selection and Data Extraction: Phase II and III trials were reviewed in our primary analysis; data from phase I trials and other studies were reported as applicable. Data Synthesis: Macitentan is a dual endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH… 

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