Machado-Joseph disease in New England: clinical description and distinction from the olivopontocerebellar atrophies.

@article{Sudarsky1992MachadoJosephDI,
  title={Machado-Joseph disease in New England: clinical description and distinction from the olivopontocerebellar atrophies.},
  author={Lewis R. Sudarsky and Luke A Corwin and David M. Dawson},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1992},
  volume={7 3},
  pages={204-8}
}
Experience is described in 25 patients from southern New England with Machado-Joseph Disease, examined serially at annual screening clinics. The disorder is dominantly inherited, with a wide range of phenotypic variation. Core clinical features described include ataxia, nystagmus, dysarthria, facial fasciculations, and lid retraction, producing a… CONTINUE READING