Macaques infected with a CCR5-tropic simian/human immunodeficiency virus (SHIV) develop broadly reactive anti-HIV neutralizing antibodies.

@article{Kraft2007MacaquesIW,
  title={Macaques infected with a CCR5-tropic simian/human immunodeficiency virus (SHIV) develop broadly reactive anti-HIV neutralizing antibodies.},
  author={Zane Kraft and Nina R Derby and Ruth A. McCaffrey and Rachel E. Niec and Wendy M Blay and Nancy L Haigwood and Eirini Moysi and Cheryl J. Saunders and Terri Wrin and Christos J. Petropoulos and M Juliana McElrath and Leonidas Stamatatos},
  journal={Journal of virology},
  year={2007},
  volume={81 12},
  pages={6402-11}
}
The development of anti-human immunodeficiency virus (anti-HIV) neutralizing antibodies and the evolution of the viral envelope glycoprotein were monitored in rhesus macaques infected with a CCR5-tropic simian/human immunodeficiency virus (SHIV), SHIVSF162P4. Homologous neutralizing antibodies developed within the first month of infection in the majority of animals, and their titers were independent of the extent and duration of viral replication during chronic infection. The appearance of… CONTINUE READING