Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission.

@article{Barouch2012MacaqueSO,
  title={Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission.},
  author={Dan Barouch and Per Johan Klasse and Jason Dufour and Ronald S Veazey and John P Moore},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 22},
  pages={
          8694-8
        }
}
Vaccination and the application of a vaginal microbicide have traditionally been considered independent methods to prevent the sexual transmission of HIV-1 to women. Both techniques can be effective in macaque models, and limited efficacy has been observed in clinical trials for each. Here, we have addressed whether vaccines and microbicides can be used together to provide reinforced protection against virus challenge of rhesus macaques. In two separate experiments, four groups of animals were… CONTINUE READING

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References

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SHOWING 1-10 OF 36 REFERENCES

Tropism-independent protection of macaques against vaginal transmission of three SHIVs by the HIV-1 fusion inhibitor T-1249.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2008
VIEW 13 EXCERPTS

How well does PREP work? Unraveling the divergent results of PrEP trials for HIV prevention

A van der Straten, L van Damme, JE Haberer, DR Bangsberg
  • AIDS 26:F13-F19
  • 2012

Mucosal SIV transmission in African Green Monkeys: Susceptibility to infection is proportional to target cell availability at mucosal sites

I Pandrea
  • J Virol
  • 2012
VIEW 1 EXCERPT