MZ3 induces apoptosis in human leukemia cells

Abstract

4-(4-Bromophenyl)-2,3-dihydro-N,3-bis(3,4,5-trimethoxyphenyl)-2-oxoidmi-dazole-1-carboxamide (MZ3) is one of the synthesized combretastatin-A-4 analogues and has been reported that it displayed a promising specific activity against leukemia cell lines. Our purpose was to investigate the mechanism of MZ3’s cytotoxicity. Cytotoxicity was measured by MTT… (More)
DOI: 10.1007/s00280-006-0294-6

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